Different batches of atorvastatin, represented by two immediate release formulation designs, were studied using a novel dynamic\ndissolution apparatus, simulating stomach and small intestine. A universal dissolution method was employed which simulated\nthe physiology of human gastrointestinal tract, including the precise chyme transit behavior and biorelevant conditions. The\nmulticompartmental dissolution data allowed direct observation and qualitative discrimination of the differences resulting from\nhighly pH dependent dissolution behavior of the tested batches. Further evaluation of results was performed using IVIVC/IVIVR\ndevelopment. While satisfactory correlation could not be achieved using a conventional deconvolution based-model, promising\nresults were obtained through the use of a nonconventional approach exploiting the complex compartmental dissolution data.
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